- Karl Murdock Bowman, MD (1943-1956)
- Alexander Simon, MD (1956-1974)
- Leon J. Epstein, MD, PhD (interim 1974-1975, interim 1985-1986)
- Robert S. Wallerstein, MD (1975-1985)
- Samuel H. Barondes, MD (1986-1993)
- Craig Van Dyke, MD (1994-2008)
- Renée L. Binder, MD (interim 2008-2011)
- Lowell Tong, MD (interim 2011-2013)
- Matthew W. State, MD, PhD (2013-present)