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Rookie Kameron Misner led off the ninth inning with his first major league home run, giving Tampa Bay a 3-2 win and becoming the first player in major league history to have his first home run be a walk-off on Opening Day.

The Diamondbacks and right-hander Brandon Pfaadt reached agreement on a five-year deal worth $45 million.

The Pirates placed second baseman Nick Gonzales on the 10-day injured list with a "non-displaced fracture of the left ankle."

Josh Lowe winced as he left the batter's box on a fifth-inning single Friday, and the Rays said he will undergo an MRI after suffering his third oblique injury in 13 months.

Brewers trade only rostered player to ever share name with team, Brewer Hicklen, to Tigers for cash.

Resorts World casino has been fined $10.5M over allegations of illegal gambling, many of which centered on a bookmaker with ties to Shohei Ohtani's former interpreter.

Set your lineups for the week ahead in fantasy baseball with our forecaster preview.

Cuba had a record 26 players on Major League Baseball's opening-day rosters, and Japan had 12 for its most since 2012.

The Yankees' spring training facility became the Rays' Opening Day ballpark in just four days. Here's how.

Nolan Arenado's eighth-inning homer Thursday had plenty of extra meaning after he spent much of the offseason on the trading block, and Cardinals fans knew it, bringing him out for a curtain call.

The Red Sox's Wilyer Abreu dedicated this two-homer game on Thursday at the Rangers to his newborn twin boys.

Astros rookie Cam Smith came through in his MLB debut, first with pregame donuts for his teammates and then a key hit in his team's 3-1 win over the Mets.

Juan Soto had a chance to play the hero in his much-anticipated Mets debut on Thursday, but he struck out swinging with two outs in the ninth inning to end the Astros' 3-1 win.

Phillies star Bryce Harper was serenaded with boos by Nationals fans on Opening Day, but got the last laugh with a solo home run in a 7-3 win over his former ballclub.

- Terry Francona's first opening day as manager of the Cincinnati Reds started in a dentist's chair.

Heliot Ramos, who became the 19th player to start in left field for the Giants over the past 19 season openers, hit a two-run home run in a victory vs. the Reds.

Orioles outfielder Tyler O'Neill extended his major league record by homering for a sixth straight Opening Day.

Liam Hendriks was placed on the 15-day injured list before the season opener at Texas because of elbow inflammation, delaying the right-hander's debut with the Red Sox after being on their roster all last season while rehabbing from Tommy John surgery.

Guardians right-hander Tanner Bibee was scratched from making his first Opening Day start due to illness.

The Chicago White Sox placed infielders Josh Rojas and Bryan Ramos and outfielder Mike Tauchman on the 10-day injured list on opening day on Thursday.