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Brewers starter Jacob Misiorowski and four relievers buried the White Sox in an avalanche of 20 strikeouts, the first time a team has recorded that many in nine innings on Opening Day.

Mets rookie Carson Benge said he "blacked out" while rounding the bases after his first home run in his major league debut. "I don't really remember too much."

Yordan Alvarez's towering shot to right field hit the roof scaffolding of Daikin Park and then ricocheted into foul territory. The Astros challenged the call, but it was upheld.

Justin Crawford batted ninth for the Phillies and went 2 for 4 with a run scored in their 5-3 opening day win over the Texas Rangers on Thursday.

After winning his debut, Nationals manager Blake Butera tried to sneak into his office. His players had other ideas, soaking the skipper with beer and shaving cream.

Yu Darvish went on the restricted list because the Padres' right-hander wants to proceed deliberately in his recovery from surgery while contemplating his future.

The percentage of players born outside the 50 states in Major League Baseball has dropped to its lowest level since 2002.

Paul Skenes recorded just two outs before being pulled from the Pirates' season opener, the shortest outing of his MLB career.

The Mets added to their depth on Opening Day, reaching a minor league deal with veteran outfielder Tommy Pham, a source told ESPN.

The Brewers placed star outfielder Chourio on the 10-day injured list on Thursday because of a fractured left hand. The move was made retroactive to Wednesday.

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Roberto Perez, a two-time Gold Glove-winning catcher who spent eight of his 10 major league seasons with Cleveland, has announced his retirement at the age of 37.

Max Fried allowed just two hits in 6 1/3 scoreless innings, and the Yankees cruised past the Giants 7-0 on Wednesday night despite Aaron Judge's first career hitless Opening Day.

Orioles second baseman Jackson Holliday will begin a rehab assignment later this week, an indication he won't miss much time with the big-league team after suffering a broken hamate bone in February.

Mariners shortstop J.P. Crawford and starting pitcher Bryce Miller will start the season on the IL as the team got down to its 26-man roster ahead of Opening Day.

Former MLB umpire Richie Garcia is worried about the impact that robot umpires will have on their human counterparts.

Pitcher Yu Darvish is expected to go on the restricted list as he spends the 2026 season recovering from elbow surgery, a decision that could free up significant payroll space for the Padres, sources told ESPN on Wednesday.

Here's your one-stop shop for all Opening Day action, starting with Wednesday's Yankees-Giants clash.