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In his first at-bat for the Yankees, Giancarlo Stanton crushed an offering from Blue Jays starter J.A. Happ for a 426-foot home run to right field.

Astros World Series MVP George Springer hit a leadoff home run on Opening Day for the second straight season. He's the only player to ever do that.

The Marlins and Cubs are wearing patches with the initials "MSD" and 17 stars, and they will host victims' families and survivors of the Parkland shooting on Friday.

UCSF researchers have shown that an experimental brain boosting drug, ISRIB, acts like a molecular staple, pinning together parts of a much larger protein involved in cellular stress.

Cubs leadoff man Ian Happ hit a home run on the first pitch that came his way, off the Miami Marlins' Jose Urena

Shohei Ohtani, in his MLB debut, will serve as the designated hitter in the Los Angeles Angels' opener against the Oakland Athletics. He will make his pitching debut on Sunday.

A small grease fire broke out at Tropicana Field before Thursday's opener for the Rays. Sprinklers were activated and the fire was extinguished, but not before smoke filled Tropicana Field.

Teams were already adding more protective netting at ballparks, but one horrific event last September galvanized baseball to do even more.

Greg Holland, who declined a $15 million player option with the Rockies for 2018 after collecting 41 saves last season, has reportedly reached a deal with the Cardinals.

Troy Tulowitzki will miss at least two months after the Blue Jays placed the shortstop on the 60-day disabled list Thursday.

The season opener between the Tigers and Pittsburgh Pirates in Detroit has been postponed to Friday because of bad weather.

Longtime New York Mets hitter Rusty Staub, who tallied 2,716 hits in a 23-year baseball career, died Thursday at the age of 73.

One Opening Day. Thirteen games -- and ESPN is at every ballpark. Here's the only URL you need on the best baseball day of the year.

When Kisha Mickels became homeless three years ago, she was looking for a lifeline to help support herself and her two kids. She found the UCSF Excellence through Community Engagement & Learning Program and now has a career at UCSF as a housing assistant.

After buying Miami Marlins tickets for each of the team's 25 seasons, Laurence Leavy, known as Marlins Man, says he won't buy tickets this year and said he's heard from other teams willing to reach a deal with him for tickets.

Sources told ESPN on Wednesday that talks between the Twins and Brian Dozier have broken down, and that the All-Star second baseman does not plan to hold any in-season discussions with the team and will hit the free-agent market in November.

Mariners left fielder Ichiro Suzuki will be in the starting lineup for Thursday's home opener against the Indians, the team announced.

Kansas City Royals manager Ned Yost has announced that catcher Salvador Perez has a grade 2 MCL tear in his left knee and is out four to six weeks. Perez suffered the injury when he slipped while carrying his luggage Tuesday night.

Want to make an opening statement? A perfect opportunity awaits in Miami. What else will decide whether Chicago lives up to the hype in 2018?

While Aaron Judge says he's excited to begin his second full season with the New York Yankees, the reigning American League Rookie of the Year says he feels no pressure coming off hitting a league-leading 52 home runs last year.