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Peter Walter, PhD, professor of biochemistry and biophysics at UCSF, has been named winner of a 2018 Breakthrough Prize in Life Sciences, for his research on a biological mechanism that normally protects cells, but can cause disease if not functioning properly.

Yankees general manager Brian Cashman told reporters Sunday night that Shohei Ohtani's representatives informed the team it will not be invited to make a presentation for the starter/sugger; Red Sox GM Dave Dombrowski said Boston is also out.

Whatever they do with Giancarlo Stanton, Derek Jeter and the Marlins will have budgetary handicaps in 2018. Where do the Fish rank among teams with major financial handicaps this winter?

The Padres signed executive vice president/general manager A.J. Preller to a three-year extension Sunday, putting him under contract through the 2022 season.

Zack Cozart and Eric Hosmer might not have many options if they're looking to strike deals with teams that have real shots of reaching the postseason.

As a manager, Aaron Boone will bring a blend of insight and analysis. But in the clubhouse? He'll add a regular guy's balance of humor and respect, for the game and for people.

Matt Adams was among those cut loose by teams unwilling to risk giving players a raise through arbitration. Which ones could be impact free agents?

The franchise-altering Japanese star is officially on the market -- and teams are salivating. But there are questions about his bat and two-way future.

The next Yankee skipper hit one of the franchise's most famous four-baggers, but has no managerial experience. Did that spook his new boss? As if.

Atlanta first baseman Matt Adams was among 26 players who gained free agency on Friday night when their former teams failed to offer them 2018 contracts. The list also includes Cubs closer Hector Rondon.

Aledmys Diaz, an All-Star as a breakout rookie for the Cardinals in 2016, was traded to the Toronto Blue Jays for minor league outfielder J.B. Woodman.

Aaron Boone, whose Game 7-winning homer in the 2003 ALCS lives on in Yankees lore, will be back in the Bronx Bombers' dugout, this time as manager, ESPN's Buster Olney reports. Boone was chosen over Hensley Meulens. This will be his first managerial job.

Representatives of slugger Giancarlo Stanton, who have met with the Giants over the past two days, have also received approval for a meeting with the Cardinals, sources told ESPN.

The next manager of the Yankees is expected to be either ESPN analyst Aaron Boone or Giants bench coach Hensley 'Bam Bam' Meulens, according to sources. General manager Brian Cashman consulted with A-Rod, but he was not a candidate.

Coming off a season in which he hit .282 with 20 homers for Baltimore, catcher Welington Castillo signed a two-year deal with the White Sox on Friday. The team also avoided arbitration with reliever Danny Farquhar.

Major League Baseball increased the number of annual drug tests from 8,281 to 10,237 in 2017, according to the sport's new independent public administrator.

Greg Holland, who had 41 saves for the Rockies, was the NL Comeback Player of the Year. The Royals' Mike Moustakas won the AL honor after belting 38 home runs.

MLB teams can begin bidding for star Shohei Ohtani after owners unanimously approved a deal for a new posting agreement with Nippon Professional Baseball.

The Japanese ace/slugger will land somewhere in the next few weeks, altering the course of a franchise. Where he ends up, though, is anyone's guess.

Much of San Francisco’s progress in fighting new HIV infections can likely be contributed to Getting to Zero – a citywide collaboration to end HIV transmission that was co-founded by UCSF.