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James Paxton is gone. Jean Segura and Kyle Seager could be next. But Seattle might be wise to hold on to Edwin Diaz and Mitch Haniger ... at least until next summer.

UCSF scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies.

With the use of relievers soaring throughout baseball, we take a look at the 10 best on the open market. And while there are several high-profile names, it's buyer beware for the biggest ones.

GMs such as the Phillies' Matt Klentak have long action lists before next season. Can they deliver on their teams' needs?

MLB is requesting a return of a $5,000 donation to Republican U.S. Senate candidate Cindy Hyde-Smith following her controversial comments and actions ahead of Tuesday's runoff election.

Some rival evaluators think Arizona is intent on dealing franchise icon Paul Goldschmidt this offseason. Who would be their most likely trade partners?

Left-handed pitcher Yusei Kikuchi will be posted by the Seibu Lions on Dec. 3 so that he can negotiate with teams in Major League Baseball.

The Royals hired former major league catcher and Cardinals manager Mike Matheny as special adviser for player development on Friday.

No player has ever been sent to Cooperstown with unanimous support. Will the former Yankees closer's case compel voters to make him the first?

Former Toronto Blue Jays slugger Jose Bautista has a new namesake buzzing around.

Shohei Ohtani says it didn't take him long to realize he was competing at a much higher level during his first season in Major League Baseball.

Marlins left-hander Dillon Peters has been traded to the Angels for minor league right-handed reliever Tyler Stevens.

The Reds and closer Raisel Iglesias have agreed to a three-year contract.

New Baltimore Orioles general manager Mike Elias called upon a familiar face to help rebuild the club, hiring former NASA engineer Sig Mejdal from the Houston Astros to be assistant general manager for analytics.

Angry, threatening and highly critical parenting is more likely to result in children with defiant, noncompliant and revengeful behavior that spills over to adulthood and impacts relationships with all authority figures. 

The Washington Nationals just signed catcher Kurt Suzuki -- but they wanted J.T. Realmuto. Miami needs to make a move before there are no more suitors left.

Manny Machado addressed his controversial "Johnny Hustle" postseason comment in an interview with MLB.com, saying that he understands how it "came across, and it's something I take responsibility for."

Your favorite team probably isn't going to get Bryce Harper or Manny Machado. But another move - maybe for a top pitcher -- could make all the difference this winter.

The Marlins have designated for assignment infielder-outfielder Derek Dietrich, who had been with the team since 2013.

The Oakland Athletics have acquired right-hander Tanner Anderson from the Pittsburgh Pirates for a player to be named later or cash.