Title: Assistant Professor in Residence
Stanford University, MD, PhD
Stanford University Medical Center, Psychiatry Residency and Research Fellowship
- What exactly are the consequences of parvalbumin interneuron hypofunction (observed in the prefrontal cortex of patients with schizophrenia) for gamma oscillations and other aspects of prefrontal microcircuit function?
- How do the effects of feedback inhibition from parvalbumin interneurons differ from those of other types of inhibition in the neocortex?
- How are gamma oscillations in different neocortical regions synchronized?
- How do oscillations in different frequency bands (theta, alpha, beta, gamma, etc.) differentially affect information processing?
- What are the biophysical bases for the effects of gamma oscillations on information processing in individual neurons and microcircuits, and how do these effects depend on cell type?
- How do recurrent excitatory synapses contribute to the propagation and processing of information in prefrontal microcircuits?
- How does activation of D1 or D2 dopamine receptors change information processing in individual neurons and microcircuits in the prefrontal cortex?
Our laboratory conducts basic science research about how microcircuits in the prefrontal cortex process information, and how this may be disrupted in psychiatric diseases such as schizophrenia. We combine several techniques including brain slice electrophysiology, cell-type specific optogenetic stimulation using channelrhodopsin, in vivo recording, behavioral assays, computational modeling, and information theory.
Information processing in neocortical microcircuits: implications for psychiatric disease
Campus Location: Parnassus
Publications on PubMed »Neurosciences and Schizophrenia Fellowship