Depression – Practicing Alternatives to Heal Depression (PATH-D) Study (CHR# 10-00455)


Do you have a patient with a history of treatment-resistant depression who has failed to respond to at least 2 adequate trials of medication during the current episode? If so, your patient may be eligible for a randomized clinical trial evaluating augmentative treatments for depression. Treatment modalities include either an 8-week training in Mindfulness-Based Cognitive Therapy (MBCT) which focuses on mindfulness meditation and awareness training, or the Health-Enhancement Program (HEP), which stresses physical fitness, diet and musical therapy for improved mental health. MBCT and HEP classes are held in the evenings at LPPI and are free of charge. Participants will be asked to complete research assessments and 2 functional Magnetic Resonance Scans (fMRI) at various time points over the duration of 1 year and will be reimbursed up to $310 for their time. As the prescribing clinician, you may be asked to verify adequate medication management and diagnosis for study entry. Exclusionary criteria for the study include current substance abuse, bipolar disorder, and any psychotic disorder such as schizophrenia. If you have a patient you think may be interested and/or eligible, please contact Erin Gillung, Research Coordinator at or 415.476.7866.


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