Depression – Brain, Biology and Mood Study
Description This study examines the relationship among depression, biological markers of stress, and brain structure in adults.
Study Design People who are interested in participating will first complete a 30 minute phone screen about their mood and health. If they seem like a good fit for the study at that point, they will be invited to come to UCSF for an in-person interview with the study coordinator and study psychiatrist to determine their full eligibility for enrollment. Once enrolled, participants will collect urine and saliva samples at home, along with some online questionnaires to be completed at their convenience. Participants will then come in for a scheduled “baseline” visit at UCSF, during which they will complete a blood draw, body measurements, cognitive tests, and will discuss their mood and recent symptoms of depression. At this point, participants can choose to continue their participation through an 8 week treatment with an antidepressant, free of charge and under supervision of the study psychiatrist. After they have been on the antidepressant for 8 weeks, they will complete the same urine and saliva sampling at home, along with the same online questionnaires, and then return to UCSF for their scheduled follow-up appointment. This follow-up appointment at UCSF will be identical to their original baseline appointment; they will complete a blood draw, body measurements, cognitive tests, and will discuss their mood and recent symptoms of depression.
End Date 3/30/2015
Participant Requirements We are currently seeking depressed men and women (ages 18-70) who are medically healthy and off all psychiatric medications for at least 6 weeks before enrolling. Participants must not have been dependent on substances in the past 6 months and must not have bipolar disorder or post-traumatic stress disorder. Female participants must not be pregnant.
Payment Up to $150 for completing the baseline hospital visit and at-home urine and saliva sampling (prorated if participants choose not to do urine and/or saliva sampling). An additional $150 will be paid to those who choose to participate in the 8 week treatment phase of the study and the follow-up hospital visit (also prorated if participants choose not to do urine and/or saliva sampling). This means that eligible participants can earn $300 if they complete all aspects of the study.